Vol. 8, Issue - 1, Part A (2024)

Emblica officinalis locally known as ‘Amloki’ has medicinal properties and used in the formulation of different Unani and Ayurvedic Medicine. Major bioactive constituents of E. officinalis are gallic acid, ascorbic acid, ellagic acid, rutin, quercetin, and catechol. It has a good reputation in Bangladesh, India and many other countries of the world as folk medicine for the treatment of a variety of diseases.

Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and eventually the failure of organs. Synthetic antidiabetic agents can produce serious side effects. In view of the adverse effects associated with the synthetic drugs and as plants are safer, cheaper and much effective, conventional antidiabetic plants can be explored. Furthermore, after the recommendation made by WHO on diabetes mellitus, investigations on hypoglycaemic agents from medicinal plants have become more important. Therefore, the present study was designed to investigate anti-hyperglycaemic effect of those plants with different doses. The anti-hyperglycaemic properties of methanolic extract of the Emblica officinalis fruits was evaluated in Swiss albino mice in order to scientifically validate its traditional therapeutic use with the different doses as per body weight.

In this experiment, among all the doses, the methanolic extract of Emblica officinalis fruit decrease the blood sugar level. The low dose (50 mg/kg body weight) decrease the glucose level but not as much as standard value. Oral administration of methanolic extract of Emblica officinalis fruit doses equivalent to 100, 200 and 400 mg/kg body weight produce significant anti-hyperglycaemic effects respectively.